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Evaluation of the use of tranexamic acid in total knee arthroplasty.
Revista Brasileira de Ortopedia 2018 November
Objective: Evaluate the efficacy of tranexamic acid in reducing bleeding in patients undergoing total knee arthroplasty.
Methods: 101 patients were randomized into two groups: the tranexamic acid group ( n = 51) and the placebo group ( n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate.
Results: Comparing the groups, there were statistically significant differences ( p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion.
Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.
Methods: 101 patients were randomized into two groups: the tranexamic acid group ( n = 51) and the placebo group ( n = 50). Patients were compared regarding the following parameters: reduction of hemoglobin, total estimated blood loss, drain output, and postoperative blood transfusion rate.
Results: Comparing the groups, there were statistically significant differences ( p < 0.05) in the following parameters: reduction of hemoglobin, decreased hematocrit, estimated blood loss, and drain output. All values were lower in the tranexamic acid group. Only placebo group patients required blood transfusion.
Conclusion: The use of intravenous tranexamic acid is effective to reduce bleeding in patients undergoing total knee arthroplasty.
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