We have located links that may give you full text access.
Circulating Inflammation-related Markers and Advanced Gastric Premalignant Lesions.
Journal of Gastroenterology and Hepatology 2018 October 25
BACKGROUND AND AIM: Chronic Helicobacter pylori infection causes gastric mucosal inflammation as an important antecedent of gastric cancer. We aimed to evaluate associations of blood markers of inflammation with gastric intestinal metaplasia and dysplasia in H. pylori-infected individuals.
METHODS: We compared pre-treatment serum levels of immune- and inflammation-related markers between 99 individuals with intestinal metaplasia or dysplasia, and 75 control individuals with non-atrophic gastritis within an H. pylori eradication trial in Mexico. Serum levels of 28 markers measured with Luminex bead-based assays were categorized in tertiles as low (T1), middle (T2) and high (T3). Logistic regression models were used to calculate age- and sex- adjusted odds ratios (OR) and 95% confidence intervals (CI). All statistical tests were two-sided and significance values were adjusted for multiple comparisons using false discovery rate (FDR) methods.
RESULTS: Five markers were nominally associated (p-trends <0.05) with the presence of advanced premalignant gastric lesions. Adjusted ORs (95% CI) of T2 and T3 vs. T1 were 4.09 (1.65-10.17) and 3.08 (1.23-7.68) for CCL3/MIP1a, 3.21 (1.33-7.75) and 2.69 (1.10-6.57) for CCL20/MIP3a levels, 1.79 (0.77-4.18) and 2.39 (1.02-5.60) for IL1β, 1.34 (0.56-3.19) and 3.02 (1.29-7.12) for IL4, and 1.07 (0.44-2.59) and 3.07 (1.32-7.14) for IL5, respectively. Two (IL4 and IL5) of the five markers had FDR adjusted p-trend <0.2.
CONCLUSIONS: Our results suggest certain Th2 and other cytokines may have a role in promoting carcinogenesis in the setting of H. pylori infection. Additional research is needed to replicate these findings, extend to pre-diagnostic samples and elucidate the underlying mechanisms.
METHODS: We compared pre-treatment serum levels of immune- and inflammation-related markers between 99 individuals with intestinal metaplasia or dysplasia, and 75 control individuals with non-atrophic gastritis within an H. pylori eradication trial in Mexico. Serum levels of 28 markers measured with Luminex bead-based assays were categorized in tertiles as low (T1), middle (T2) and high (T3). Logistic regression models were used to calculate age- and sex- adjusted odds ratios (OR) and 95% confidence intervals (CI). All statistical tests were two-sided and significance values were adjusted for multiple comparisons using false discovery rate (FDR) methods.
RESULTS: Five markers were nominally associated (p-trends <0.05) with the presence of advanced premalignant gastric lesions. Adjusted ORs (95% CI) of T2 and T3 vs. T1 were 4.09 (1.65-10.17) and 3.08 (1.23-7.68) for CCL3/MIP1a, 3.21 (1.33-7.75) and 2.69 (1.10-6.57) for CCL20/MIP3a levels, 1.79 (0.77-4.18) and 2.39 (1.02-5.60) for IL1β, 1.34 (0.56-3.19) and 3.02 (1.29-7.12) for IL4, and 1.07 (0.44-2.59) and 3.07 (1.32-7.14) for IL5, respectively. Two (IL4 and IL5) of the five markers had FDR adjusted p-trend <0.2.
CONCLUSIONS: Our results suggest certain Th2 and other cytokines may have a role in promoting carcinogenesis in the setting of H. pylori infection. Additional research is needed to replicate these findings, extend to pre-diagnostic samples and elucidate the underlying mechanisms.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app