We have located links that may give you full text access.
[Regeneration of corneal nerve after SMILE, FS-LASIK and T-PRK surgery and study its relationship with subjective visual quality].
[Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology 2018 October 12
Objective: To explore nerve fiber regeneration and subjective visual quality of patients undergoing small incision lenticule extraction (SMILE) surgery, femtosecond laser-assisted in-situ keratomileusis (FS-LASIK) and transepithelial photorefractive keratectomy (T-PRK), and study their correlation. Methods: This is a prospective cohort study including 55 patients (6 male, 49 female, age 25.6±7.3, in total 109 eyes) who chose refractive surgery in Peking Union Medical College Hospital. They are subdivided into 3 groups: 35 patients in SMILE (4 male, 31 female), 9 patients in FS-LASIK (1 male, 8 female) and 11 patients in T-PRK (1 male, 10 female). All surgeries were conducted by the same surgeon. Patients underwent confocal microscopy examinations and filled in subjective visual quality questionnaires before surgery and 7 days, 30 days and 90 days after surgery. ACCMterics V.2 was used for nerve analysis. One-way analysis of variance, Kruskal-Wallis H test and Pearson correlation study was adopted for data analysis on SPSS 22.0. Results: Corneal nerve fiber density is lowest at 7 days after surgery. The nerve fiber length (8.53 (7.32), 9.33 (6.47), 10.98 (4.85) mm/mm(2), χ(2)=9.21, 8.15, 6.54; P< 0.05), density (12.50 (12.50), 12.50 (12.50), 18.75 (14.06)/mm(2), χ(2)=6.54, 9.02, 7.01; P< 0.05) and total branch density (18.75 (31.25), 24.99 (29.69), 31.25 (32.81)/mm(2), χ(2)=10.23, 7.63, 10.01; P< 0.05) of SMILE group are significantly higher than the other 2 groups at 7 days, 30 days and 90 days after surgery. The subjective visual quality scores are (4.13±0.61), (3.54±0.71), (4.03±0.70) and (4.20±0.58) respectively at each visit, with 7 days being the lowest ( F= 1.51, P= 0.23), but there is no statistically significant difference between each group at each visit. At 7 days after surgery, the nerve fiber length (CNFL) and nerve fiber density (CNBD) show strong positive correlation with overall subjective visual quality ( r= 0.378, 0.504; P< 0.05), while there exists no significant correlation between nerve fiber parameters and subjective visual quality 30 days and 90 days after surgery. Conclusions: SMILE shows better results in corneal nerve fiber regeneration. Corneal nerve fiber density of early post-operational period is positively correlated with overall subjective visual quality. (Chin J Ophthalmol, 2018, 54: 737 - 743) .
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app