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Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells: Characterization, Differentiation, and Applications in Cartilage Tissue Engineering

Xu Li, Mingjie Wang, Xiaoguang Jing, Weimin Guo, Chunxiang Hao, Yu Zhang, Shuang Gao, Mingxue Chen, Zengzeng Zhang, Xueliang Zhang, Shi Shen, Bin Zhang, Hai Xian, Zehao Wang, Yu Wang, Xiang Sui, Aiyuan Wang, Jiang Peng, Shibi Lu, Shuyun Liu, Quanyi Guo
Critical Reviews in Eukaryotic Gene Expression 2018, 28 (4): 285-310
30311578
Articular cartilage defects have very limited self-repair potential, and traditional bone marrow-stimulating therapy is not effective. Cartilage tissue engineering using bone marrow mesenchymal stem cells (BMSCs) and adipose tissue-derived mesenchymal stem cells (ADSCs) is considered an attractive treatment for cartilage lesions and osteoarthritis. However, studies proved that both BMSCs and ADSCs have their own advantages and shortcomings, including their sources, isolation methods, characterizations and differentiation potential. Understanding the properties and differences between ADSCs and BMSCs is important for clinical application in cartilage regeneration. This review provides an overview of BMSCs and ADSCs based on their characterization, isolation. Then, we summarized their differentiation potential in different experimental conditions. Finally, we discuss the applications of BMSCs and ADSCs in scaffold-free and scaffold-based cartilage tissue engineering. Based on different properties of BMSCs and ADSCs, and patient's physical condition, a more suitable therapeutic strategy can be selected.

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