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Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging.

Walter A Rocca, Liliana Gazzuola Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, James L Kirkland, Nathan K LeBrasseur, Marissa J Schafer, Michelle M Mielke, Kejal Kantarci, Elizabeth A Stewart, Virginia M Miller
Physiology 2018 November 2
Bilateral oophorectomy in premenopausal women is a unique condition causing the abrupt and premature loss of ovarian hormones, primarily estrogen. Bilateral oophorectomy causes an alteration of several fundamental aging processes at the cellular, tissue, organ, and system levels, leading to multimorbidity, frailty, and reduced survival. However, many questions remain unanswered.

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