The Space Between: A Previously Unrecognized and Pervasive Space in the Body May Hold Solutions for Cancer Metastasis, Immunotherapy, and Fibrosis Treatment.

Around 2008, endoscopists David Carr-Locke and Petros Benias began to notice an unfamiliar pattern in the bile duct during endomicroscopy, which didn't look like anything they knew from pathology. Their confusion as to what it was persisted, so they brought their observations to their colleague, pathologist Neil Theise. Eventually, a larger group of researchers worked to figure out what exactly they were seeing in the bile duct samples. Their ultimate conclusion was that the structure is part of a network of connected interstitial spaces.