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Sirt1 protects neural stem cells from apoptosis by decreasing acetylation of histone 3K9.
Objective: To explore the role and mechanism of Sirt1 in protecting neural stem cells (NSCs) from apoptosis.
Materials and methods: Transfection was used to overexpress Sirt1 in rat NSCs. The effect of Sirt1 overexpression on camptothecin-induced apoptosis of NSCs was evaluated. Western blotting was used to examine the expression of Sirt1, cleaved caspase-3, and acetylated histone 3K9.
Results: Overexpression of Sirt1 in NSCs decreased the cleavage of caspase-3 and acetylation of histone 3K9.
Conclusion: Sirt1 may protect NSCs from apoptosis by decreasing the acetylation of histone 3 on K9.
Materials and methods: Transfection was used to overexpress Sirt1 in rat NSCs. The effect of Sirt1 overexpression on camptothecin-induced apoptosis of NSCs was evaluated. Western blotting was used to examine the expression of Sirt1, cleaved caspase-3, and acetylated histone 3K9.
Results: Overexpression of Sirt1 in NSCs decreased the cleavage of caspase-3 and acetylation of histone 3K9.
Conclusion: Sirt1 may protect NSCs from apoptosis by decreasing the acetylation of histone 3 on K9.
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