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Short-term changes in added sugar consumption by adolescents reflected in the carbon isotope ratio of fingerstick blood

Sarah V Liu, Lori B Moore, Tanya M Halliday, A Hope Jahren, Jyoti Savla, Valisa E Hedrick, Elaina L Marinik, Brenda M Davy
Nutrition and Health 2018 September 20, : 260106018799522

BACKGROUND: Consumption of added sugars (AS) and sugar-sweetened beverages (SSB) may adversely affect adolescents' weight and cardiovascular disease risk. Reliance on self-reported dietary assessment methods is a common research limitation, which could be overcome by dietary intake biomarkers.

AIM: The investigation was a proof-of-concept study to evaluate the proposed carbon isotope ratio (δ13 C) biomarker of AS intake in adolescents, using a controlled feeding design.

METHODS: Participants ( n = 33, age 15.3 years, 53% female) underwent two seven-day controlled feeding periods in a randomly assigned order. Diets were matched in composition except for AS content (5% or 25% of total energy). Fasting fingerstick blood samples were collected daily during each diet period.

RESULTS: Fingerstick δ13 C values changed from day 1 to 8 by -0.05 ± 0.071‰ on 5% AS, and +0.03 ± 0.083‰ on 25% AS ( p ≤ 0.001). Reliability was demonstrated between day 7 and 8 δ13 C values on the 5% (ICC = 0.996 , p ≤ 0.001) and 25% (ICC = 0.997, p ≤ 0.001) AS diets.

CONCLUSIONS: Larger scale investigations are warranted to determine if this technique could be applied to population-level research in order to help assess the effectiveness of interventions aimed at reducing the consumption of AS or SSB intake.


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