We have located links that may give you full text access.
A catalase-loaded hierarchical zeolite as an implantable nanocapsule for ultrasound-guided oxygen self-sufficient photodynamic therapy against pancreatic cancer.
Nanoscale 2018 September 21
Photodynamic therapy (PDT) is an alternative strategy for treating pancreatic cancer (PC) in clinics. However, the therapeutic efficacy is generally suppressed by inadequate oxygen supply in the hypoxic tumor microenvironment. Herein, hierarchical zeolite nanocarriers with hydrophilic mesoporous nanostructures and excellent biodegradability are synthesized via a one-pot wet chemical method. By co-loading with catalase and methylene blue (MB), a new type of oxygen self-sufficient PDT platform, a zeolite-catalase-MB nanocapsule (ZCM nanocapsule), is developed. After precision implantation of the ZCM nanocapsule into the tumor area under the real-time ultrasound (US) imaging guidance, the nanocapsule with 90% relative activity of equivalent free catalase enzyme efficiently modulates the tumor hypoxia and enhances the intratumoral US contrast by sustained decomposition of endogenous H2O2 and in situ production of O2 gas bubbles. Meanwhile, the MB loading in hierarchical zeolite matrices prevents the rapid leaching of the photosensitizer in tumor tissue, achieving a good sustained photosensitizer release effect. Based on the synchronous mechanisms, upon near-infrared laser irradiation, the local PC cells are completely killed, and no therapy-induced toxicity and recurrence are observed. This highly biocompatible and biodegradable hierarchical nanozeolite would further facilitate the development of catalase-based catalytic nanomedicine for enhancing chemotherapy, radiotherapy and combination therapy.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app