Heart Failure with Urine Microalbumin, Hs-CRP, BNP and Troponin and Effects of Levocarnitine on These Indicators.

OBJECTIVE: To investigate the effects of levocarnitine on cardiac function, urinary albumin, high-sensitivity C-reactive protein (hs-CRP), brain natriuretic peptide (BNP) and troponin in patients with coronary heart disease and heart failure.

METHODS: 246 patients with CHD-caused HF was selected and randomly divided into Group A and Group B. A fully automatic biochemical analyzer was used to measure the levels of ALB, Hs-CRP, BNP and troponin in two groups of patients, and the expression levels of LVDD and LVEF were detected by cardiac color ultrasonography. Patients in Group A were intravenously injected with 3.0 g levocarnitine, once per day. After 14 d, the changes in levels of ALB, Hs-CRP, BNP, troponin, LVDD and LVEF in patients in Group A were detected.

RESULTS: The effective cure rates of two groups were 65.8% and 81.3%, respectively, and there was a statistically significant difference between two groups (p<0.05). After administration of levocarnitine, all indexes showed decreasing trends, but LVEF level increased. Among them, patients treated with levocarnitine showed the most obvious decreases of LVEF. Decrease in BNP was the largest (p<0.05). And there was no statistical difference in incidence rate between two groups (5.8% vs. 2.5%, p=0.222).

CONCLUSION: L-carnitine can effectively improve ALB, Hs-CRP, BNP, troponin, LVDD expression, so as to improve cardiac function rating, improve cardiac function.