Is Empirical Anti-tuberculous Treatment Justified Even in the Second Decade of the 21st Century?

Tuberculosis (TB) is a highly prevalent disease in developing countries where there is poor sanitation, over-crowding and malnutrition. It can affect various organ systems in our body including the central nervous system, respiratory, genito-urinary tract and bone, though respiratory involvement is by far the commonest. Though diagnostic modalities for TB are well defined, empirical therapy without a confirmed diagnosis continues to be used in specific clinical situations. We report two cases with suspected TB who served empirical treatment.