We have located links that may give you full text access.
Development of 3D scaffolds using nanochitosan/silk-fibroin/hyaluronic acid biomaterials for tissue engineering applications.
International Journal of Biological Macromolecules 2018 December
Bone tissue engineering put emphasis on fabrication three-dimensional biodegradable porous scaffolds that supporting bone regeneration and functional bone tissue formation. In the present work, we prepared novel 3D tripolymeric scaffolds of nanochitosan (NCS)/silk fibroin (SF)/hyaluronic acid (HA) ternary blends and demonstrating the synergistic effect of scaffolds and its use in tissue engineering applications. The physico-chemical characterization of the prepared scaffold was evaluated by FTIR, XRD and SEM studies. The FT-IR and XRD results confirmed the interfacial bonding interaction existing between polymers. SEM images showed good interconnected porous structure with rough surface morphology. The in vitro cytocompatibility tests carried out with osteoblast cells by the MTT assay demonstrated that the blended scaffold favors the early adhesion, growth and proliferation of preosteoblast MC3T3-E1 cells. The alizarin red assay indicated that the prepared scaffold can promote the osteogenic differentiation and facilitate the calcium mineralization of MC3T3-E1 cells. The alkaline phosphatase assay confirmed that the NCS/SF/HA scaffold provide conducive environment for osteoblast proliferation and mineral deposition. The bactericidal action of NCS/SF/HA scaffold reveals that the prepared sample has the potential to kill the microorganisms to a greater extent. Hence the overall findings concluded that the NCS/SF/HA scaffolds have better applications in tissue engineering.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app