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RESEARCH SUPPORT, NON-U.S. GOV'T
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Poor codon optimality as a signal to degrade transcripts with frameshifts.

Miquel Àngel Schikora-Tamarit, Lucas B Carey
Transcription 2018
Frameshifting errors are common and mRNA quality control pathways, such as nonsense-mediated decay (NMD), exist to degrade these aberrant transcripts. Recent work has shown the existence of a genetic link between NMD and codon-usage mediated mRNA decay. Here we present computational evidence that these pathways are synergic for removing frameshifts.

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