Read by QxMD icon Read

A randomised controlled trial exploring the effects of different beverages consumed alongside a nitrate-rich meal on systemic blood pressure

Sinead Tj McDonagh, Lee J Wylie, Paul T Morgan, Anni Vanhatalo, Andrew M Jones
Nutrition and Health 2018, 24 (3): 183-192

BACKGROUND: Ingestion of nitrate (NO3 - )-containing vegetables, alcohol and polyphenols, separately, can reduce blood pressure (BP). However, the pharmacokinetic response to the combined ingestion of NO3 - and polyphenol-rich or low polyphenol alcoholic beverages is unknown.

AIM: The aim of this study was to investigate how the consumption of low and high polyphenolic alcoholic beverages combined with a NO3 - -rich meal can influence NO3 - metabolism and systemic BP.

METHODS: In a randomised, crossover trial, 12 normotensive males (age 25 ± 5 years) ingested an acute dose of NO3 - (∼6.05 mmol) in the form of a green leafy salad, in combination with either a polyphenol-rich red wine (NIT-RW), a low polyphenol alcoholic beverage (vodka; NIT-A) or water (NIT-CON). Participants also consumed a low NO3 - salad and water as a control (CON; ∼0.69 mmol NO3 - ). BP and plasma, salivary and urinary [NO3 - ] and nitrite ([NO2 - ]) were determined before and up to 5 h post ingestion.

RESULTS: Each NO3 - -rich condition elevated nitric oxide (NO) biomarkers when compared with CON ( P < 0.05). The peak rise in plasma [NO2 - ] occurred 1 h after NIT-RW (292 ± 210 nM) and 2 h after NIT-A (318 ± 186 nM) and NIT-CON (367 ± 179 nM). Systolic BP was reduced 2 h post consumption of NIT-RW (-4 mmHg), NIT-A (-3 mmHg) and NIT-CON (-2 mmHg) compared with CON ( P < 0.05). Diastolic BP and mean arterial pressure were also lower in NIT-RW and NIT-A compared with NIT-CON ( P < 0.05).

CONCLUSIONS: A NO3 - -rich meal, consumed with or without an alcoholic beverage, increases plasma [NO2 - ] and lowers systemic BP for 2-3 h post ingestion.


You need to log in or sign up for an account to be able to comment.

No comments yet, be the first to post one!

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"