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REVIEW ARTICLE: Cellular Abnormalities and Emerging Biomarkers in Alcohol Associated Liver Disease

Ashwani K Singal, Shannon M Bailey
Gene Expression 2018 July 25
30086817
Alcohol associated liver disease (AALD) is the third most common preventable cause for disease burden and mortality in the US. AALD including alcoholic hepatitis (AH) contributes to half of admissions from decompensated liver disease and 20% of all liver transplants in the US. Peripheral blood cells contribute to systemic inflammation, oxidative stress, mitochondrial dysfunction, and fibrosis in AALD and AH. Alcohol dysregulates function of lymphocytes, neutrophils, monocytes, and tissue macrophages of the innate immune system. These alterations in turn can modulate adaptive immune responses. In this review, we will describe these disruptive effects of alcohol on cells of the innate and adaptive immune system and focus on cellular based emerging biomarkers on diagnosis and prognosis of patients with AALD and AH.

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