Add like
Add dislike
Add to saved papers

Bloodstream infections caused by Klebsiella pneumoniae: prevalence of bla KPC , virulence factors and their impacts on clinical outcome.

BACKGROUND: Klebsiella pneumoniae bloodstream infections (BSIs) occur with significant prevalence and high mortality worldwide. Antimicrobial resistance and virulence are two main factors participating in the pathogenicity of K. pneumoniae. Here we investigated the prevalence of blaKPC and virulence factors in K. pneumoniae isolated from patients with BSIs and their association with clinical outcome.

METHODS: The clinical data of 285 K. pneumoniae BSI cases diagnosed from January 2013 to December 2015 in a Chinese university hospital were retrospectively evaluated. The "string test" was performed to identify hypermucoviscous K. pneumoniae (HMKP). blaKPC , rmpA, magA and serotype-specific genes were detected by PCR amplification. Finally, a Cox proportional hazards model was employed to determine the predictors of 14-day mortality.

RESULTS: Of these isolates, the prevalence of blaKPC and rmpA were 33.3% (95/285) and 31.6% (90/285) respectively. 69 isolates (24.2%, 69/285) were HMKP. rmpA was strongly associated with HM phenotype. The KPC-producing KP and HMKP were almost non-overlapping and only three HMKP isolates harbored blaKPC . K1 (28, 40.6%) and K2 (22, 31.9%) were the most common serotypes in HMKP. 44.9% of HMKP BSIs had origin of biliary tract infection or liver abscess. The 14-day mortality was 100% in blaKPC + /HM+ subgroup (3/3), followed by blaKPC + /HM- (39/92, 42.4%), blaKPC - /HM+ (5/66, 7.6%) and blaKPC - /HM- (7/124, 5.6%). The 14-day cumulative survival was significantly different between blaKPC + and blaKPC - subgroup (Log-rank p < 0.001) but almost equal between blaKPC - /HM+ and blaKPC - /HM- subgroup (Log-rank p = 0.578) under the condition of comparable illness severity between blaKPC - /HM+ and blaKPC - /HM- subgroup. Independent risk factors for 14-day mortality were Pitt bacteremia score (HR 1.24, CI 95% 1.13-1.36, p < 0.001), Charlson comorbidity index (HR 1.24, CI 95% 1.09-1.41, p = 0.001), septic shock (HR 2.61, CI 95% 1.28-5.35, p = 0.009) and blaKPC (HR 2.20, CI 95% 1.06-4.54, p = 0.034).

CONCLUSIONS: Most of HMKP were antibiotic-susceptible and people infected received appropriate antimicrobial therapy, which may explain the favorable outcome of HMKP BSIs. The KPC-producing HMKP BSIs were scarce but life-threatening. blaKPC was valuable in predicting 14-day mortality.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app