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MitraClip in Patients With Mitral Regurgitation and Left Ventricular Ejection Fraction <30% - Potential Implications for the Treatment of Patients in Japan.
BACKGROUND: The effect of the unique Japanese indication for MitraClip based on left ventricular ejection fraction (LVEF) is unclear. Methods and Results: We analyzed 874 patients who underwent MitraClip because of mitral regurgitation (MR) and compared the characteristics and outcomes between patients with LVEF <30% and ≥30%. Patients with LVEF ≤30% accounted for 33% of the study population and had a higher prevalence of functional MR. Severity of MR after MitraClip was comparable, and LVEF <30% did not independently affect survival.
CONCLUSIONS: Japanese unique indication based on LVEF may exclude one third of patients who were treated with MitraClip in Europe.
CONCLUSIONS: Japanese unique indication based on LVEF may exclude one third of patients who were treated with MitraClip in Europe.
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