We have located links that may give you full text access.
Transforming Growth Factor- β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients.
Background: Transforming growth factor- β (TGF- β ) may inhibit the development of atherosclerosis. We evaluated serum levels of TGF- β isoforms concurrently with serum levels of endotoxin and various inflammatory markers. In addition, we determined if any association exists between polymorphisms in the TGF-β1 gene and atherosclerosis in South African CKD patients.
Methods: We studied 120 CKD patients and 40 healthy controls. Serum TGF- β 1, TGF- β 2, TGF- β 3, endotoxin, and inflammatory markers were measured. Functional polymorphisms in the TGF-β1 genes were genotyped using a polymerase chain reaction-sequence specific primer method and carotid intima media thickness (CIMT) was assessed by B-mode ultrasonography.
Results: TGF- β isoforms levels were significantly lower in the patients with atherosclerosis compared to patients without atherosclerosis (p<0.001). Overall, TGF- β isoforms had inverse relationships with CIMT. TGF- β 1 and TGF- β 2 levels were significantly lower in patients with carotid plaque compared to those without carotid plaque [TGF- β 1: 31.9 (17.2 - 42.2) versus 45.9 (35.4 - 58.1) ng/ml, p=0.016; and TGF- β 2: 1.46 (1.30 - 1.57) versus 1.70 (1.50 - 1.87) ng/ml, p=0.013]. In multiple logistic regression, age, TGF- β 2, and TGF- β 3 were the only independent predictors of subclinical atherosclerosis in CKD patients [age: odds ratio (OR), 1.054; 95% confidence interval (CI): 1.003 - 1.109, p=0.039; TGF- β 2: OR, 0.996; 95% CI: 0.994-0.999, p=0.018; TGF- β 3: OR, 0.992; 95% CI: 0.985-0.999, p=0.029). TGF-β1 genotypes did not influence serum levels of TGF- β 1 and no association was found between the TGF-β1 gene polymorphisms and atherosclerosis risk.
Conclusion: TGF- β isoforms seem to offer protection against the development of atherosclerosis among South African CKD patients.
Methods: We studied 120 CKD patients and 40 healthy controls. Serum TGF- β 1, TGF- β 2, TGF- β 3, endotoxin, and inflammatory markers were measured. Functional polymorphisms in the TGF-β1 genes were genotyped using a polymerase chain reaction-sequence specific primer method and carotid intima media thickness (CIMT) was assessed by B-mode ultrasonography.
Results: TGF- β isoforms levels were significantly lower in the patients with atherosclerosis compared to patients without atherosclerosis (p<0.001). Overall, TGF- β isoforms had inverse relationships with CIMT. TGF- β 1 and TGF- β 2 levels were significantly lower in patients with carotid plaque compared to those without carotid plaque [TGF- β 1: 31.9 (17.2 - 42.2) versus 45.9 (35.4 - 58.1) ng/ml, p=0.016; and TGF- β 2: 1.46 (1.30 - 1.57) versus 1.70 (1.50 - 1.87) ng/ml, p=0.013]. In multiple logistic regression, age, TGF- β 2, and TGF- β 3 were the only independent predictors of subclinical atherosclerosis in CKD patients [age: odds ratio (OR), 1.054; 95% confidence interval (CI): 1.003 - 1.109, p=0.039; TGF- β 2: OR, 0.996; 95% CI: 0.994-0.999, p=0.018; TGF- β 3: OR, 0.992; 95% CI: 0.985-0.999, p=0.029). TGF-β1 genotypes did not influence serum levels of TGF- β 1 and no association was found between the TGF-β1 gene polymorphisms and atherosclerosis risk.
Conclusion: TGF- β isoforms seem to offer protection against the development of atherosclerosis among South African CKD patients.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app