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Clinical Application of 2017 McDonald Diagnostic Criteria for Multiple Sclerosis

Vittorio Mantero, Lucia Abate, Roberto Balgera, Loredana La Mantia, Andrea Salmaggi
Journal of Clinical Neurology 2018, 14 (3): 387-392

BACKGROUND AND PURPOSE: McDonald criteria for multiple sclerosis diagnosis have been revised over the years, diagnostic procedures have been simplified and earlier diagnosis facilitated. The new 2017 revision introduces other important changes, with a further simplification for the diagnosis. Oligoclonal bands reassume a more relevant role in the workup.

METHODS: We describe 3 typical cases of patients admitted for clinically isolated syndrome and illustrate how the application of the new criteria can change the diagnostic approach with respect to the previous criteria.

RESULTS: In two of the three cases a diagnosis of multiple sclerosis is now possible.

CONCLUSIONS: The new 2017 Multiple Sclerosis criteria may have an important impact in clinical practice with an earlier treatment to avoid the risk of disease dissemination. Their application requires a careful assessment to avoid misdiagnosis and mistreatments.

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