A systematic review about prophylactic L-carnitine administration in parenteral nutrition of extremely preterm infants.

OBJECTIVE: Preterm infants with total parenteral nutrition are at particular risk of developing carnitine deficiency with impaired tolerance of parenteral lipids. The  objective was to review the scientific literature on potencial benefits of  prophylactic L-carnitine administration in parenteral nutrition of preterm  newborns.

METHODS: Selected scientific articles in MEDLINE/PubMed, Scopus, The Cochrane Library, British Library EThOS and TESEO databases were assessed for this  systematic review. The terms used as descriptors were «Total Parenteral  Nutrition» and «Carnitine». Jadad scale was chosen to evaluate the quality of  them.

RESULTS: 18 out of the 93 references retrieved were selected for reviewing after  applying the inclusion and exclusion criteria, 4 of them were discarded for being  considered of low quality. Almost all studies agreed on the analytical variables  measured (free carnitine and acylcarnitine, triglycerides, free fatty acids and  ketone bodies). Other clinical variables such as weight gain, apnea, or lenght of  stay at hospital were also considered.

CONCLUSIONS: The present results prove that routine supplementation in the  parenteral nutrition of preterm newborns may help to increase carnitine levels,  but neither a relevant improvement in the lipid profile, or an increase in weight  gain, or a decrease in morbimortality or reduction of hospital stay could be  demonstrated. More studies are needed in preterm infants to know whether  routine supplementation of L-carnitine in neonates requiring total parenteral  nutrition for a long time would provide any clinical benefit.