Memantine induces manic episode in a 73-year-old patient with vascular neurocognitive disorder: a case report

Jinfeng Duan, Chengming Lao, Jingkai Chen, Fen Pan, Chenlin Zhang, Weijuan Xu, Weihua Zhou, Jianbo Hu, Desheng Shang, Manli Huang, Yi Xu
Neuropsychiatric Disease and Treatment 2018, 14: 1395-1398
Memantine, an N -methyl-d-aspartate receptor antagonist, is a well-established treatment option for moderate-to-severe cognitive impairment related to Alzheimer disease. Recently, growing evidence has indicated memantine might also be effective in treatment of affective disorders. The common drug-induced adverse events of memantine include confusion, dizziness, drowsiness, headache, insomnia, and agitation. Herein, we presented a case of a 73-year-old female patient with vascular neurocognitive disorder, who developed a manic episode after taking memantine.

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