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Journal Article
Review
Pharmacoepidemiology in Pharmacogenetics.
Epidemiologic methods provide rigorous means by which to study the interplay between genetic factors and drug response. In this chapter, we describe the differences between experimental and observational study designs, and illustrate how to implement the highly efficient case-control study design. We discuss analytic approaches to evaluating gene-drug interactions within typical study designs and review sources of bias that must be assessed and accounted for in epidemiologic analyses.
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