MENU ▼
Read by QxMD icon Read
search
OPEN IN READ APP
JOURNAL ARTICLE

Clinical significance of platelet-to-lymphocyte ratio in women with preeclampsia

Min-A Kim, Gwan Hee Han, Ja-Young Kwon, Young-Han Kim
American Journal of Reproductive Immunology: AJRI 2018, 80 (1): e12973
29781540

PROBLEM: Preeclampsia (PE) is a serious pregnancy complication leading to high maternal, perinatal morbidity, and mortality. We aimed to investigate the clinical effectiveness of the platelet-to-lymphocyte ratio (PLR) in women with PE and compare this measurement to platelet indices as a diagnostic and prognostic marker of PE.

METHOD OF STUDY: A total of 471 healthy pregnant women, 126 women diagnosed with mild PE, and 227 with severe PE were included in this retrospective study. We analyzed PLR and platelet indices, mainly mean platelet volume (MPV) and platelet distribution width (PDW) among the 3 groups.

RESULTS: Platelet distribution width, MPV, and PLR levels in women with PE were significantly different from those of healthy pregnant women. PLR was significantly lower in severe PE than mild PE (P = .001), but PDW and MPV increased as severity of PE progressed; however, the differences in PDW and MPV between women with mild and severe PE were not significant. Receiver operating characteristic curve analysis showed that PLR was more predictive of PE than PDW and MPV (Area under the curve = 0.759 vs 0.621, 0.638). Additionally, the time interval from admission to delivery was significantly shorter in women with PLR-positive (≤116) than in women with PDW-positive (>58) and MPV-positive (>9).

CONCLUSION: The PLR is an easily accessible and cost-effective parameter, which may be used as a more useful marker for prediction of PE compared to platelet indices. Our study showed that PLR can serve as a useful diagnostic marker of PE.

Comments

You need to log in or sign up for an account to be able to comment.

No comments yet, be the first to post one!

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read
29781540
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"