Mechanisms and Management of Acute Pancreatitis

Ari Garber, Catherine Frakes, Zubin Arora, Prabhleen Chahal
Gastroenterology Research and Practice 2018, 2018: 6218798
Acute pancreatitis represents a disorder characterized by acute necroinflammatory changes of the pancreas and is histologically characterized by acinar cell destruction. Diagnosed clinically with the Revised Atlanta Criteria, and with alcohol and cholelithiasis/choledocholithiasis as the two most prominent antecedents, acute pancreatitis ranks first amongst gastrointestinal diagnoses requiring admission and 21st amongst all diagnoses requiring hospitalization with estimated costs approximating 2.6 billion dollars annually. Complications arising from acute pancreatitis follow a progression from pancreatic/peripancreatic fluid collections to pseudocysts and from pancreatic/peripancreatic necrosis to walled-off necrosis that typically occur over the course of a 4-week interval. Treatment relies heavily on fluid resuscitation and nutrition with advanced endoscopic techniques and cholecystectomy utilized in the setting of gallstone pancreatitis. When necessity dictates a drainage procedure (persistent abdominal pain, gastric or duodenal outlet obstruction, biliary obstruction, and infection), an endoscopic ultrasound with advanced endoscopic techniques and technology rather than surgical intervention is increasingly being utilized to manage symptomatic pseudocysts and walled-off pancreatic necrosis by performing a cystogastrostomy.


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Esther Cohen

Thank you for this paper. What would you suggest for primary care presentation with pathology slightly elevated and patient mildly symptomatic? Not unwell enough for an admission but requires monitoring. No food and high liquid intake until symptoms subside? Ultrasound outpatient and then education and care plan- weight loss, alcohol cessation etc after episode?



Very good


Ramses Perez

excelente artículo, sencillo y puntual


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