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What Is the Role of α-Blockers for Medical Expulsive Therapy? Results From a Meta-analysis of 60 Randomized Trials and Over 9500 Patients

Omar M Aboumarzouk, Patrick Jones, Tarik Amer, Dimitris Kotsiris, Esteban Emiliani, Bhaskar Somani, Panagiotis Kallidonis, Thomas Tailly, Gohkan Atis, Francesco Greco, Stephan Hruby, Mario Alvarez, Khalid Al-Rumaihi, Ahmad Shamsodini, Abdulla Al-Ansari, Ahmed Shokeir
Urology 2018, 119: 5-16
29626570
Use of α-blockers for medical expulsive therapy (MET) has been the subject of huge debate in urology. Moreover, there have been a number of randomized controlled trials with differing results. We conducted a systematic review and meta-analysis of randomized controlled trials investigating the efficacy of α-blockers for MET. This review confirms there is a role for α-blockers in MET for ureteric stones specifically in stones >5 mm and distal ureteric stones, which is associated with improved stone expulsion. However, there is a slight increase in risk of nonsignificant side effects.

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