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JOURNAL ARTICLE
The Not-So-Soft Spot: Pathophysiology of the Bulging Fontanelle in Association With Roseola.
Pediatric Emergency Care 2020 October
Roseola infantum is a clinical syndrome characterized by high fever followed by the emergence of a rash. Case reports have documented an association between bulging fontanelles and roseola. We propose a novel mechanism for the development of intracranial hypertension caused by human herpesvirus 6-induced cytokine elevation leading to increased cerebrospinal fluid production.
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