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Journal Article
Research Support, Non-U.S. Gov't
Review
Biological alterations affecting risk of adult psychopathology following childhood trauma: A review of sex differences.
Clinical Psychology Review 2018 December
Childhood trauma exposure is a significant public health problem. While adult mental health consequences of such experiences are well documented, sex differences in both prevalence and severity are less understood. Sex-based differences in biological circuitry and physiological trauma responses are proposed to potentiate the differential risk for pathogenesis of mental health disorders among adults. This paper will provide a contextualized summary of neuroendocrine, neuroimaging, and behavioral epigenetic studies on biological sex differences contributing to internalizing psychopathology, specifically posttraumatic stress disorder and depression, among adults with a history of childhood abuse. This review concludes with a discussion of implications for trauma interventions and sex-based biopsychological research in violence prevention.
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