[VIPoma : a rare etiology of diarrhea with hypokalemia]

Raphaël André, Thibaud Koessler, Damien Polet, Arnaud Roth, Marc Ritz, Omar Kherad
Revue Médicale Suisse 2018 January 31, 14 (592): 289-293
VIPoma or Verner Morrison syndrome is a very rare disease with an incidence rate of 1 case per 10 000 000 person-years. It is a neuroendocrine tumor issue from β-pancreatic islets leading to profuse diarrhea, hypokalemia and gastric achlorydria due to secretion of vasoactive intestinal polypeptide (VIP) hormone. Diagnosis is based on histology of tumor and the dosage of VIP in a blood sample. Somatostatin analog is a simple and efficient treatment for diarrhea. Curative treatment with surgery could be proposed for a localized disease. For disseminated disease, there are different treatments and a multimodal assessment that should be discussed in a multidisciplinary team might be curative.

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