Mass and Charge Measurements on Heavy Ions.

The relationship between mass and charge has been a crucial topic in mass spectrometry (MS) because the mass itself is typically evaluated based on the m / z ratio. Despite the fact that this measurement is indirect, a precise mass can be obtained from the m / z value with a high m / z resolution up to 105 for samples in the low mass and low charge region under 10,000 Da and 20  e , respectively. However, the target of MS has recently been expanded to the very heavy region of Mega or Giga Da, which includes large particles and biocomplexes, with very large and widely distributed charge from kilo to Mega range. In this region, it is necessary to evaluate charge and mass simultaneously. Recent studies for simultaneous mass and charge observation and related phenomena are discussed in this review.