JOURNAL ARTICLE

SEOM clinical guideline on unknown primary cancer (2017)

F Losa, G Soler, A Casado, A Estival, I Fernández, S Giménez, F Longo, R Pazo-Cid, J Salgado, M Á Seguí
Clinical & Translational Oncology 2018, 20 (1): 89-96
29230692
Cancer of unknown primary site is a histologically confirmed cancer that manifests in advanced stage, with no identifiable primary site following standard diagnostic procedures. Patients are initially categorized based on the findings of the initial biopsy: adenocarcinoma, squamous-cell carcinoma, neuroendocrine carcinoma, and poorly differentiated carcinoma. Appropriate patient management requires understanding several clinical and pathological features that aid in identifying several subsets of patients with more responsive tumors.

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