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Analysis of lipid metabolism and its impact on the risk of ischemic heart disease in patients with definite familial hypercholesterolemia.
Atherosclerosis. Supplements 2017 November
AIM: to analyze the relationship between lipid disturbance, including lipoprotein(a) (Lp(a)) levels, and development of ischemic heart disease (IHD) in patients with familial hypercholesterolemia (FH).
MATERIALS AND METHODS: 81 patients (middle age was 39.1 ± 0.4 years, 33 males, 48 females) with a definite FH were examined. The concentration of Lp(a) was determined by immunoturbidimetric method. Lipid profiles were estimated by enzymatic colorimetric method.
RESULTS: Lp(a) levels were elevated in 41.9% of FH patients. In FH patients with elevated Lp(a) (>0.3 g/l) IHD occurred 1.7 times more often, myocardial infarction - 2.76 times. The risk of IHD in FH patients was increased in individuals with Lp(a) 1.2 g/l and above.
CONCLUSION: Lp(a) elevation plays an additional role in IHD appearance in FH.
MATERIALS AND METHODS: 81 patients (middle age was 39.1 ± 0.4 years, 33 males, 48 females) with a definite FH were examined. The concentration of Lp(a) was determined by immunoturbidimetric method. Lipid profiles were estimated by enzymatic colorimetric method.
RESULTS: Lp(a) levels were elevated in 41.9% of FH patients. In FH patients with elevated Lp(a) (>0.3 g/l) IHD occurred 1.7 times more often, myocardial infarction - 2.76 times. The risk of IHD in FH patients was increased in individuals with Lp(a) 1.2 g/l and above.
CONCLUSION: Lp(a) elevation plays an additional role in IHD appearance in FH.
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