[Advances in the diagnosis and hormone replacement treatment of 46, XY disorders of sex development]

Hong-Juan Tian, Jian-Wei Zhang, De-Hua Wu, Da-Xing Tang, Jun-Fen Fu
Zhonghua Nan Ke Xue, National Journal of Andrology 2016, 22 (9): 843-849
Disorders of sex development (DSD) is defined as a congenital condition or atypical development of the chromosomal, gonadal, or anatomic sex. The diagnosis, gender assignment, and treatment of DSD require the guidance from experienced multidisciplinary teams. So far there has been no consensus about it in China. Due to dysgenetic gonads, defects in sex steroid biosynthesis or action, or gonadectomy during the prepubertal years, those with DSD suffer from hypogonadism. The hormone replacement therapy of DSD aims at general physiological health and long-term prognosis as well as the avoidance of unnecessary genital and gonadal surgery. This review focuses on the advances in the studies of the diagnosis and hormone replacement therapy of 46,XY DSD.

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