A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit

Johnny Kopinja, Raquel S Sevilla, Diane Levitan, David Dai, Amy Vanko, Edward Spooner, Chris Ware, Robert Forget, Kun Hu, Astrid Kral, Peter Spacciapoli, Richard Kennan, Lata Jayaraman, Vincenzo Pucci, Samanthi Perera, Weisheng Zhang, Christian Fischer, Michael H Lam
Scientific Reports 2017 October 23, 7 (1): 13853
Mutations in IDH1 are highly prevalent in human glioma. First line treatment is radiotherapy, which many patients often forego to avoid treatment-associated morbidities. The high prevalence of IDH1 mutations in glioma highlights the need for brain-penetrant IDH1 mutant-selective inhibitors as an alternative therapeutic option. Here, we have explored the utility of such an inhibitor in IDH1 mutant patient-derived models to assess the potential therapeutic benefits associated with intracranial 2-HG inhibition. Treatment of mutant IDH1 cell line models led to a decrease in intracellular 2-HG levels both in vitro and in vivo. Interestingly, inhibition of 2-HG production had no effect on in vitro IDH1 mutant glioma cell proliferation. In contrast, IDH1 mutant-selective inhibitors provided considerable survival benefit in vivo. However, even with near complete inhibition of intratumoral 2-HG production, not all mutant glioma models responded to treatment. The results suggest that disruption of 2-HG production with brain-penetrant inhibitors in IDH1 mutant gliomas may have substantial patient benefit.

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