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Poly( N -(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer Nanocarriers.

Jawaher A Alfurhood, Hao Sun, Christopher P Kabb, Bryan S Tucker, James H Matthews, Hendrik Luesch, Brent S Sumerlin
Polymer Chemistry 2017 September 15
We report nanoassemblies based on block copolymers of N -(2-hydroxypropyl) methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units. Drug release via ester hydrolysis suggests this approach offers potential for stimuli-responsive drug delivery under acidic conditions.

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