JOURNAL ARTICLE
REVIEW

Nephrotic syndrome in infants and children: pathophysiology and management

Mallory L Downie, Claire Gallibois, Rulan S Parekh, Damien G Noone
Paediatrics and International Child Health 2017, 37 (4): 248-258
28914167
Nephrotic syndrome is defined by nephrotic-range proteinuria (≥40 mg/m2 /hour or urine protein/creatinine ratio ≥200 mg/mL or 3+ protein on urine dipstick), hypoalbuminaemia (<25 g/L) and oedema. This review focuses on the classification, epidemiology, pathophysiology, management strategies and prognosis of idiopathic nephrotic syndrome of childhood, and includes a brief overview of the congenital forms.

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