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Superior Fluorogen-Activating Protein Probes Based on 3-Indole-Malachite Green

Qingyang Zhang, Qinghua Wang, Ying Sun, Limin Zuo, Verena Fetz, Hai-Yu Hu
Organic Letters 2017 September 1, 19 (17): 4496-4499
A series of novel fluorogenic dyes based on 3-indole-Malachite Green, MGs 5-7, have been developed that are dark in solution but highly fluorescent when bound to the cognate reporter, fluorogen-activating protein (FAP). Significantly, the new MGs 5-7 probes are superior to the traditional MG 1 with high fluorescent efficiency and low toxicity to cells while maintaining the large "pseudo-Stokes" shifts (Δλ = λex - λem ) and the malachite green (MG)-like fluorescence OFF-ON switching mechanism in both live mammalian cells and bacterial cells when bound to FAP.


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