The mercury-203 method for evaluating metallothioneins: interference by copper, mercury, oxygen, silver and selenium

P B Lobel, J F Payne
Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology 1987, 86 (1): 37-9
Metallothioneins are low molecular weight proteins rich in sulfhydryl groups (cysteinyl) which readily bind various heavy metal cations, e.g. cadmium, copper, gold, mercury, silver and zinc. Mercury has a particular affinity for sulfhydryl groups and mercury-203 has been used as the basis of a rapid, sensitive, radiometric assay for metallothionein. The potential of 16 metals and oxygen for interfering with this test was examined. The mercury-203 test appears to be sensitive to the presence of copper, mercury, oxygen, selenium and silver.

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