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Off-Label Use of Bedaquiline in Children and Adolescents with Multidrug-Resistant Tuberculosis.

Jay Achar, Cathy Hewison, Ana P Cavalheiro, Alena Skrahina, Junia Cajazeiro, Parpieva Nargiza, Krzysztof Herboczek, Assliddin S Rajabov, Jennifer Hughes, Gabriella Ferlazzo, James A Seddon, Philipp du Cros
Emerging Infectious Diseases 2017 October
We describe 27 children and adolescents <18 years of age who received bedaquiline during treatment for multidrug-resistant tuberculosis. We report good treatment responses and no cessation attributable to adverse effects. Bedaquiline could be considered for use with this age group for multidrug-resistant tuberculosis when treatment options are limited.

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