Read by QxMD icon Read

Vitamin D deficiency impairs testicular development and spermatogenesis in mice

Lin Fu, Yuan-Hua Chen, Shen Xu, Yan-Li Ji, Cheng Zhang, Hua Wang, De-Xin Yu, De-Xiang Xu
Reproductive Toxicology 2017, 73: 241-249
Vitamin D deficiency is prevalent especially in men. Nevertheless, whether vitamin D deficiency impairs male reproduction remains under debate. The aim of this study is to investigate whether vitamin D deficiency has an impact on testicular development and spermatogenesis in mice. In the control group and vitamin D deficient (VDD) diet group, dams and their pups were fed with standard-chow diet and VDD diet, respectively. Interestingly, testicular weight and sperm quality are reduced, testicular germ cell proliferation is suppressed, and the percentage of mature seminiferous tubules is decreased in VDD diet-fed mice. Moreover, testicular testosterone (T) synthesis enzymes are down-regulated in VDD diet-fed mice. Correspondingly, serum and testicular T levels are reduced in VDD diet-fed mice. Importantly, fertility index is reduced and live fetuses are decreased when both males and females are fed with VDD diet. These results provide evidence that vitamin D deficiency impairs testicular development and spermatogenesis.


You need to log in or sign up for an account to be able to comment.

No comments yet, be the first to post one!

Trending on Read

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"