Association between serum 25(OH) vitamin D and metabolic disturbances in polycystic ovary syndrome.

BACKGROUND: To assess the relationship between serum 25(OH) vitamin D levels and metabolic parameters together with androgenic hormone levels in women with polycystic ovary syndrome (PCOS).

METHODS: This is a single-centre study from the Endocrinology Institute at Firouzgar Hospital in Iran. Seventy-three women aged 15-45 years were recruited from May 2013 to December 2013. Serum 25(OH) vitamin D level, other laboratory biomarkers and anthropometric indexes were measured. Data were analysed with statistical software SPSS version 16.0 for windows and we used specific analytical tests to assess data.

RESULTS: Serum 25(OH) vitamin D levels were < 20 ng/ml in 64 patients (79%). Nine patients (12.3%) were diagnosed with metabolic syndrome. A significant difference was found between the women with and without severe vitamin D deficiency with regard to waist circumference, fasting insulin level and HOMA-IR, and abnormal systolic and diastolic blood pressures. The serum 25(OH) vitamin D levels had a reverse but weak correlation with systolic and diastolic blood pressures.

CONCLUSION: This study showed an association between serum 25(OH) vitamin D levels and some metabolic parameters; however, there was no significant linear correlation between serum 25(OH) vitamin D levels and metabolic variables, except for systolic and diastolic blood pressure.