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Sarcopenia: An Overview on Current Definitions, Diagnosis and Treatment

Francesco Landi, Riccardo Calvani, Matteo Cesari, Matteo Tosato, Anna Maria Martone, Elena Ortolani, Giulia Savera, Sara Salini, Alex Sisto, Anna Picca, Emanuele Marzetti
Current Protein & Peptide Science 2018 May 14, 19 (7): 633-638
28595526
Sarcopenia, the progressive and generalized loss of skeletal muscle mass and strength/function associated with aging, increases the risk of a vast array of adverse health outcomes, including falls, morbidity, loss of independence, disability, and mortality. As such, sarcopenia poses a huge socioeconomic burden in developed countries. The development and implementation of effective interventions against sarcopenia are therefore a public health priority. A preliminary, fundamental step in such a process entails the agreement of researchers, healthcare professionals and policymakers around a unique operational definition of sarcopenia. This will facilitate the framing of a clear clinical entity to be incorporated in standard practice, the understanding of the underlying pathophysiology, and the identification of biological targets for drug development.

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