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Prospective study of cancer in patients with hypogammaglobulinaemia.

L J Kinlen, A D Webster, A G Bird, R Haile, J Peto, J F Soothill, R A Thompson
Lancet 1985 Februrary 3
Among 377 patients with primary hypogammaglobulinaemia, mainly common variable immunodeficiency (CVID), 316 patients survived the first 2 years after diagnosis and were the subject of a study of cancer incidence. Among the 220 patients with CVID, there was a 5-fold increase of cancer due mainly to large excesses of stomach cancer (47-fold) and lymphomas (30-fold). The excess of stomach cancer is probably related to the high frequency of achlorhydria in CVID. 3 of the 7 patients with stomach cancer and CVID survived for 5 years or longer.

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