We have located links that may give you full text access.
COMPARATIVE STUDY
IN VITRO
JOURNAL ARTICLE
REVIEW
Diabetic penile neuropathy.
Urologic Clinics of North America 1988 Februrary
In vitro studies strongly suggest the presence of autonomic neuropathy in impotent patients with diabetes mellitus. Morphologic studies reveal structural damage to the penile autonomic nerves. Biochemical, histochemical, and immunohistochemical evidence suggests a general depletion of the adrenergic, cholinergic, and NANC neurotransmitter systems that control penile erection. These in vitro studies on human tissue are, however, not performed with appropriate control tissue from potent patients with diabetes mellitus. For this reason, it is important to study diabetic penile neuropathy by developing animal models. The investigative work by Crowe and Fani in streptozocin-induced diabetes mellitus is encouraging, but more research efforts should be directed toward this objective. Clinical testing is needed to assess the functionality of the autonomic corporal nerves objectively. At present, the patient's erectile response to an intracavernosal injection of vasoactive agents is being studied. If there is an isolated autonomic neuropathy, as commonly exists in young patients with spinal cord injury, the erectile response to the intracavernosal injection is immediate and complete. This intracavernosal injection test for autonomic neuropathy records hemodynamic and not neurophysiologic responses. In patients with an accompanying hemodynamic impairment, such as cavernosal artery insufficiency or corporal veno-occlusive dysfunction, as commonly exists in patients with diabetes mellitus, the hemodynamic erectile response to the intracavernosal injection is impaired, and the presence or absence of autonomic neuropathy is subsequently masked.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app