Chronic Blood Pressure Reductions and Increments in Plasma Nitric Oxide Bioavailability

Crisieli M Tomeleri, Alexandre J Marcori, Alex Silva Ribeiro, Aline Mendes Gerage, Camila de Souza Padilha, Durcelina Schiavoni, Mariana F Souza, Jerry L Mayhew, Matheus Amarante do Nascimento, Danielle Venturini, Decio Sabbatini Barbosa, Edilson Serpeloni Cyrino
International Journal of Sports Medicine 2017, 38 (4): 290-299
This study analyzed the effects of 12 weeks of resistance training (RT) on resting blood pressure (BP) and plasma levels of nitric oxide metabolites (NOx) in pre- and hypertensive older women, and evaluated the relationship between these 2 parameters. Thirty-five older women (68.2±5.7 years, 70.0±14.4 kg, 157.1±6.4 cm, 28.3±5.0 kg.m-2) were randomly allocated into a training group (TG; n=17), which performed a 12-week RT program, and a control group (CG; n=18), which did not perform any physical exercise. Anthropometry, one repetition maximum (1RM), body composition analysis by dual energy X-ray absorptiometry, blood samples, and resting BP were measured. There was a significant interaction for all variables analyzed, in which reductions of systolic BP (-8.5%), diastolic BP (-8.4%), and mean arterial pressure (-8.5%), and increases of NOx (+35.2%) were observed only for the TG. Moreover, a negative and significant correlation was observed (P<0.05; r=-0.63) between NOx and systolic BP in the TG. Results suggest that a 12-week RT program is sufficient to induce reductions in BP in pre- and hypertensive older women and that the decrease in systolic BP is associated with an increase in plasma NOx concentration.


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