[Optimization of conservation regimes and processes of regeneration of organs and tissues in surgery and transplantology using mathematical methods of planning experiments]

A N Lisenkov, V I Tel'pukhov, S I Boltrukevich, I A Bashilov, K N Uglianitsa
Vestnik Akademii Meditsinskikh Nauk SSSR 1989, (7): 69-74
The experience of using mathematical planning of an experiment in solving problems of multifactor optimisation in surgery and transplantology is discussed, including optimisation of heart and bone tissue preservation with low-dose aldehydes and antioxidants, study of the effects of retabolil on gastroenteroanastomosis regeneration, and optimisation of ischaemic damage prevention with low-dose aldehydes. In solving these problems, multifactor economical plans were initially applied to identify the optimal variants for several outputs. Second-order plans were further employed to specify the optimal regimes and construct models describing the optimum region. Recommendations on the choice of the most rational and time-saving regimes have been elaborated.

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