Effects and Prevalence of Non-Responders after 12weeks of High-Intensity Interval or Resistan Training in Adult Woman with Insulin Resistance:A Randomized Trial

Cristian Alvarez, Rodrigo Ramírez-Campillo, Robinson Ramírez-Vélez, Mikel Izquierdo
Journal of Applied Physiology 2017 February 2, : jap.01037.2016

AIMS/HYPOTHESIS: Our aim was to investigate the effects and prevalence of non-responders (NR) to high-intensity interval training (HIIT) and resistant training (RT)in adult woman with insulin resistance on cardiometabolic health parameters.

METHODS: Sedentary overweight/obese insulin resistant adult women (age = 33.5 ±6.5 years;BMI=29.9 ± 3.7kg/m2) were randomly assigned to a tri-weekly HIIT program(HIIT;n=18) or resistant training (RT;n=17).Anthropometry (body mass, fat mas, muscle mass, waist circumference and skinfolds thickness),cardiovascular(blood pressure), metabolic (fasting glucose, fasting insulin and HOMA-IR),as well muscle strength, and endurance performance co-variables were measured before and after 12 weeks in both intervention groups.The interindividual variability to exercise training of the subjects was categorized as responders (R),and NR using as cut-points two times the typical error of measurement in mean outcomes.

RESULTS: Significant differences in the NR prevalence between the HIIT and RT groups were identified for a decrease in fat mass (HIIT 33.3% vs.RT 70.5%,P=0.028), muscle mass (HIIT 100% vs.RT 52.9%,P=0.001), and tricipital skinfold (HIIT 5.5%vs.RT 29.4%, P<0.061).For diastolic blood pressure, significant differences were observed in the NR prevalence between the HIIT and RT groups (55.5% vs.94.1,P=0.009). However, there were no differences in the NR prevalence between HIIT and RT for decreasing fasting glucose Conclusions/interpretation: 12-weeks of HIIT and RT have similar effects and NR prevalence to improve anthropometry, cardiovascular and glucose control variables; however, there is different NR prevalence in other anthropometric, cardiovascular, strength and endurance performance measurements in insulin resistant adult woman. These findings were displayed with a similar time investment/week of 114 vs.108 min,respectively to HIIT and RT.


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