JOURNAL ARTICLE
REVIEW

Chemical screening in zebrafish for novel biological and therapeutic discovery

D S Wiley, S E Redfield, L I Zon
Methods in Cell Biology 2017, 138: 651-679
28129862
Zebrafish chemical screening allows for an in vivo assessment of small molecule modulation of biological processes. Compound toxicities, chemical alterations by metabolism, pharmacokinetic and pharmacodynamic properties, and modulation of cell niches can be studied with this method. Furthermore, zebrafish screening is straightforward and cost effective. Zebrafish provide an invaluable platform for novel therapeutic discovery through chemical screening.

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