Acquired hemophagocytic syndrome in a patient with synovial sarcoma: a case report

Chiara Ciccarese, Roberto Ferrara, Emanuela Fantinel, Camilla Zecchetto, Francesca Simionato, Elisabetta Grego, Silvia Ortolani, Mario Caccese, Davide Bimbatti, Sara Cingarlini, Matteo Brunelli, Angelo Andreini, Giampaolo Tortora, Francesco Massari
Future Science OA 2015, 1 (4): FSO29
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by severe hyperinflammation due to an overwhelming ineffective immune response to different triggers. Most important symptoms are fever, hepatosplenomegaly and cytopenias. Biochemical signs include elevated ferritin, hypertriglyceridemia and low fibrinogen. Hemophagocytosis in the bone marrow is a hallmark of this syndrome. Based on the pathogenetic mechanism, it can be classified into primary (inherited) or secondary (acquired) HLH. We report, to our knowledge, the first case of acquired hemophagocytic syndrome that arose in a 20-year-old man affected by synovial sarcoma as a complication during chemotherapy.

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