Calcium-dependent dynamic changes in the subcellular distribution of calmodulin in frog spinal cells

S Adachi, J I Oka, H Fukuda
Brain Research 1989 May 15, 487 (1): 196-9
Calcium-dependent changes in the subcellular distribution of calmodulin (CaM) were investigated using isolated intraarterially perfused frog spinal cords. Perfusion with quin2-tetraacetoxymethyl ester (Q2-AM), an intracellular Ca2+-chelator, increased soluble CaM, measured by radioimmunoassay (RIA), with a concomitant decrease in particulate CaM. By contrast, in synaptosomes, Q2-AM increased soluble CaM and total CaM but not particulate CaM. These results suggest that intracellular Ca2+ controls the binding of CaM to membranes in spinal cells.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Trending Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"