JOURNAL ARTICLE

Calcium-dependent dynamic changes in the subcellular distribution of calmodulin in frog spinal cells

S Adachi, J I Oka, H Fukuda
Brain Research 1989 May 15, 487 (1): 196-9
2787689
Calcium-dependent changes in the subcellular distribution of calmodulin (CaM) were investigated using isolated intraarterially perfused frog spinal cords. Perfusion with quin2-tetraacetoxymethyl ester (Q2-AM), an intracellular Ca2+-chelator, increased soluble CaM, measured by radioimmunoassay (RIA), with a concomitant decrease in particulate CaM. By contrast, in synaptosomes, Q2-AM increased soluble CaM and total CaM but not particulate CaM. These results suggest that intracellular Ca2+ controls the binding of CaM to membranes in spinal cells.

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