JOURNAL ARTICLE
REVIEW

Malignant Peripheral Nerve Sheath Tumor

Aaron W James, Elizabeth Shurell, Arun Singh, Sarah M Dry, Fritz C Eilber
Surgical Oncology Clinics of North America 2016, 25 (4): 789-802
27591499
Malignant peripheral nerve sheath tumor (MPNST) is the sixth most common type of soft tissue sarcoma. Most MPNSTs arise in association with a peripheral nerve or preexisting neurofibroma. Neurofibromatosis type is the most important risk factor for MPNST. Tumor size and fludeoxyglucose F 18 avidity are among the most helpful parameters to distinguish MPNST from a benign peripheral nerve sheath tumor. The histopathologic diagnosis is predominantly a diagnosis of light microscopy. Immunohistochemical stains are most helpful to distinguish high-grade MPNST from its histologic mimics. Current surgical management of high-grade MPNST is similar to that of other high-grade soft tissue sarcomas.

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